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Hémisynthèse d'un nouvel isomère de la vinblastine |
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| Authors: | N Kunesch P -L Vaucamps A Cav J Poisson |
| Institution: | C.N.R.S., ERA 317, Centre d'Etudes Pharmaceutiques 92290 - CHATENAY-MALABRY, FRANCE Department of Chemistry, Rice University HOUSTON, TEXAS 77001, U.S.A. |
| Abstract: | The reaction of the chloroindolenine of secopandoline with vindoline in acidic medium gives an isomer of the antitumor vinblastine . This new compound is 14′-epi-20′-epivinblastine . |
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