Vibrational spectroscopy of articular cartilage |
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| Authors: | Lassi Rieppo Juha Töyräs Simo Saarakkala |
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| Institution: | 1. Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland;2. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland;3. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland;4. Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland;5. Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland;6. Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland |
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| Abstract: | Articular cartilage is a connective tissue that is located at the ends of long bones. Type II collagen, proteoglycans, water, and chondrocytes are the main constituents of articular cartilage. Osteoarthritis, the most common joint disease in the world, causes degenerative changes in articular cartilage tissue. Fourier transform infrared, Raman, and near infrared spectroscopic techniques offer versatile tools to assess biochemical composition and quality of articular cartilage. These vibrational spectroscopic techniques can be used to broaden our understanding about the compositional changes during osteoarthritis, and they also hold promise in disease diagnostics. In this article, the current literature of articular cartilage spectroscopic studies is reviewed. |
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| Keywords: | Articular cartilage infrared spectroscopy microscopy near-infrared spectroscopy osteoarthritis Raman spectroscopy |
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