A Novel Medium Poly(vinyl acetate-triallyl isocyanurate-divinylbenzene) Coupled with Oligo-β-Cyclodextrin for the Isolation of Puerarin from Pueraria Flavones |
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Authors: | Rong Li Rui Zhao Haiyang Zhang Cong Li Di Feng Peiyong Qin Tianwei Tan |
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Institution: | 1. Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 100029, China
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Abstract: | Poly(vinyl acetate-triallyl isocyanurate-divinylbenzene) matrix coupled with oligo-β-cyclodextrin was synthesized to separate puerarin. The separation of three isoflavone homologues, puerarin, daidzin and daidzein, was achieved by increasing the proportion of methanol from 40 to 85%. The interaction mechanism between the crosslinkers and puerarin was investigated through molecular dynamics simulation and the mixed-mode character was demonstrated by computational and conformational methods. The research confirms that in order to enhance the recognition, the addition of triallyl isocyanurate is feasible. Meanwhile, an alternative matrix for the separation of puerarin was provided, with the advantages of moderate mechanical rigidity, ease of modification and low cost. |
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