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Comparison of RP, Ion-Pair and IE Chromatography Coupled with UV and Tandem Mass Spectrometry for the Determination of 8-Hydroxyquinoline in Cosmetics |
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| Authors: | Qiang Ma Chao Wang Hua Bai Wei Ma Xin Zhou Yiyang Dong Qing Zhang |
| Institution: | 1. Chinese Academy of Inspection and Quarantine, 100123, Beijing, China 2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 100085, Beijing, China 3. China Agriculture University, 100083, Beijing, China 4. Heilongjiang Entry-Exit Inspection and Quarantine Bureau, 150086, Harbin, China |
| Abstract: | Liquid chromatographic methods based on reversed-phase, ion-pair and ion-exchange chromatography coupled with ultraviolet spectrometry and tandem mass spectrometry have been developed and compared for the determination of 8-hydroxyquinoline in cosmetic samples. The individual parameters of different techniques are systematically optimized. The reversed-phase chromatography using ultrasonic extraction, centrifugation and filtration prior to LC–UV and LC–MS–MS detection was selected to be the general analytical method for the routine analysis of 8-hydroxyquinoline in cosmetics due to its simplicity, column reproducibility and sensitivity. The procedure is rapid, simple and suitable for the quality control of cosmetic preparations. The application of this technique to the assay of commercial products is also presented. |
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