Simple and Efficient Procedure for Highly Diastereoselective Synthesis of trans- 1,1-Disubstituted-2,6-diarylcyclohexane-4-ones |
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| Authors: | YU Ya-qin WANG Zhong-liang |
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| Institution: | 1. Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal University, Tianjin 300387, P. R. China;
2. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, P. R. China |
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| Abstract: | A simple and efficient method has been developed for highly diastereoselective synthesis of trans-1,1-disubstituted-2,6-diarylcyclohexane-4-ones from dibenzalacetone and malononitril with trans-1,2-diami-nocyclohexane as catalyst. The substrate 1,5-diaryl-1,4-pentadien-3-ones and active methylene compounds proceeded to give the products with good to excellent yield within a short time. |
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| Keywords: | Substituted cyclohexanone Double Michael addition Malononitrile |
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