Preparation of 7-alkylamino-2-methylquinoline-5,8-diones |
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| Authors: | Choi Han Young Kim Dong Wook Chi Dae Yoon Yoon Eun Young Kim Dong Jin |
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| Affiliation: | Division of Applied Sciences, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 136-791, Korea. |
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| Abstract: | Several novel 7-alkylamino-2-methylquinoline-5,8-diones (2) were synthesized from 2,5-dimethoxyaniline in five steps via the Skraup reaction followed by demethylations, oxidative bromination, amination, and debromination. We have achieved an unusual hydrobromic acid catalyzed debromination reactions of several 6-bromo-7-alkylamino-2-methylquinoline-5,8-diones, giving 7-alkylamino-2-methylquinoline-5,8-diones in good yields. |
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