Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi |
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Authors: | Huang Hui-Chi Tsai Wei-Jern Liaw Chia-Ching Wu Shih-Hsiung Wu Yang-Chang Kuo Yao-Haur |
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Affiliation: | Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan. |
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Abstract: | Bioassay-directed fractionation of an ethanolic extract of the galls of Sapindus mukorossi has resulted in the isolation of two new tirucallane-type triterpenoid saponins, sapinmusaponins Q (1) and R (2), along with three known oleanane-type triterpenoid saponins (3-5). Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin. |
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