Toward general access to the aspidosperma-type terpenoid indole alkaloids: synthesis of the key 3,3-disubstituted piperidones through enantioselective intramolecular heck-type reaction of chloroformamides |
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Authors: | Yasui Yoshizumi Takeda Hiroshi Takemoto Yoshiji |
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Institution: | Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. |
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Abstract: | An enantioselective intramolecular Heck-type reaction of chloroformamides has been developed for the synthesis of 3,3-disubstituted piperidones. The desired piperidone was formed in the presence of a palladium catalyst, an optically active phosphoramidite ligand, K3PO4 and Ag3PO4. The obtained piperidone was converted to epieburnamonine. |
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