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Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues |
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| Authors: | Liang You Wan Nian Zhang Zhen Yuan Miao Wei Guo Xiao Ying Che Wen Ya Wang Chun Quan Sheng Jiang Zhong Yao Ting Zhou |
| Affiliation: | School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
| Abstract: | Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method.The results showed that some of the compound had higher antitumor activity than iritecan. |
| Keywords: | Homocamptotbecin Amino acids ester Antitumor activity Synthesis |
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