| N-取代靛蓝衍生物的合成及其抗癌活性研究 |
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| 引用本文： | 孟继本,李平,何永志,徐黎立,王永梅.N-取代靛蓝衍生物的合成及其抗癌活性研究[J].高等学校化学学报,2001,22(Z1):63-65. |
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| 作者姓名： | 孟继本 李平 何永志 徐黎立 王永梅 |
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| 作者单位： | 南开大学化学系, 天津 300071 |
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| 基金项目： | 国家自然科学基金(批准号:29832030和20072018)重点资助. |
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| 摘 要： | 合成了13种N-取代靛蓝衍生物,其中6种为新化合物.研究了靛蓝的N-取代衍生物与抗痛活性的关系,发现大多数N-取代靛蓝衍生物与靛玉红有相似的抗癌活性,某些甚至离于綻玉红的抗癌活性.
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| 关 键 词： | 靛蓝 靛玉红 抗癌活性 |
| 文章编号： | 0215-0790(2001)10Z-63-03 |
| 收稿时间： | 2001-06-25 |
| 修稿时间： | 2000年6月25日 |
Study on the Anticancer Activity of Indigo Derivatives |
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| MENG Ji-Ben,LI Ping,HE Yong-Zhi,XU Li-Li,WANG Yong-Mei.Study on the Anticancer Activity of Indigo Derivatives[J].Chemical Research In Chinese Universities,2001,22(Z1):63-65. |
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| Authors: | MENG Ji-Ben LI Ping HE Yong-Zhi XU Li-Li WANG Yong-Mei |
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| Institution: | Department of Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | Thirteen compounds of indigo derivatives were synthesized, among which six compounds were first synthesized, The structure of all the new compounds have been comfirmed by 1H NMR, MS and elemental analysis. The relationship between the compound's structure and anticancer activity was studied. It was found that most of the indigo derivatives have the similar anticancer activity to indirubin, and some superior than indirubin. |
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| Keywords: | Indigo Indirubin Anticancer activity |
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