Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium |
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| Authors: | Chan Wing-Kei Ho Chi-Ming Wong Man-Kin Che Chi-Ming |
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| Institution: | Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China. |
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| Abstract: | A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal alpha-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions. |
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