High-Performance liquid chromatographic separation of enantiomers of unusual amino acids possessing cycloalkane or cycloalkene skeletons on a chiral crown ether containing stationary phase |
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| Authors: | G Török A Péter F Fülöp |
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| Institution: | 1. Department of Inorganic and Analytical Chemistry, Attila József University, P.O. Box 440, 6701, Szeged, Hungary
2. Institute of Pharmaceutical Chemistry, Albert Szent-Gy?rgyi University, P.O. Box 121, 6701, Szeged, Hungary
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| Abstract: | Summary Direct reversed-phase high-performance liquid chromatographic methods were developed for the separation and identification
of the enantiomers of mono- and bicyclic racemic β-amino acids:cis- andtrans-2-aminocyclopentane-1-carboxylic acids,cis- andtrans-2-aminocyclohexane-1-carboxylic acids,cis- andtrans-2-amino-4-cyclohexene-1-carboxylic acids,diendo- anddiexo-3-aminobicyclo2.2.1]heptane-2-carboxylic acids anddiendo- anddiexo-3-amino-5-bicyclo2.2.1]heptene-2-carboxylic acids. Enantioseparation was carried out by the application of a chiral stationary
phase, Crownpak CR(+). The conditions of separation were optimized by changing the temperature, the flow rate and the pH of
the mobile phase.
Presented at: Balaton Symposium on High-Performance Separation Methods, Siófok, Hungary, September 3–5, 1997. |
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| Keywords: | Column liquid chromatography Crownpak CR(+) Column Cyclic β -Amino Acids |
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