Convenient syntheses of pyrazolo[3,4-b]pyridin-6-ones using either microwave or ultrasound irradiation |
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Authors: | Cláudio E Rodrigues-SantosAurea Echevarria |
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Institution: | Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, 23890-900 Seropédica, RJ, Brazil |
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Abstract: | An efficient synthesis of 12 pyrazolo3,4-b]pyridin-6-one derivatives was achieved using either microwave or ultrasound irradiation, resulting in yields of 40-60% and 60-95%, respectively. Under our conditions, these reactions occurred with notably reduced reaction times as compared to literature reports involving traditional heating. Furthermore, these reactions were highly regioselective and produced only one pyrazolo3,4-b]pyridin-6-one isomer, whose identity was confirmed by NOESY spectroscopy. |
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Keywords: | Pyrazolo[3 4-b]pyridin-6-ones Microwave Ultrasound |
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