A novel synthetic approach towards pyrazole-4-carboxamides using N-(3-(dimethylamino)-2-formylacryloyl)formamide |
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| Authors: | Madhukar N. Jachak Maruti G. Ghagare Dilip R. Birari Ramhari V. Rote Muddassar A. Kazi Sanjay M. Jachak Raghunath B. Toche |
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| Affiliation: | (1) Department of Chemistry, Organic Chemistry Research Centre, K.T.H.M. College, Gangapur Road, Nashik, 422002, Maharashtra, India;(2) National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Mohali, 160062, Punjab, India |
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| Abstract: | Abstract A novel synthesis of pyrazole-4-carboxamides is reported. The reaction of N-(3-(dimethylamino)-2-formylacryloyl)formamide, an intermediate obtained by Vilsmeier–Haack formylation of acetonitrile, with hydrazine hydrate or monosubstituted hydrazines provides such compounds in good yields. This method has advantages over other methods for construction of such ring systems previously described in the literature. |
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