Modification of biologically active amides and amines with fluorine-containing heterocycles 1. Novel fluorine-containing heterocyclic derivatives of streptocide |
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Authors: | Sokolov V. B. Aksinenko A. Yu. Epishina T. A. Goreva T. V. Martynov I. V. |
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Affiliation: | 1.Institute of Physiologically Active Substances, Russian Academy of Sciences, 1 Severnyi proezd, Chernogolovka, 142432, Moscow Region, Russian Federation ; |
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Abstract: | Three-component reaction of Piracetam, methyl trifluoropyruvate and 1,3-binucleophiles, such as 6-aminouracils, 6-aminothiouracils, 4-(4-tolylamino)pent-3-en-2-one and N-substituted ureas, has been studied. This reaction resulted in fluorinated heterocyclic derivatives of Piracetam. |
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