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Modification of biologically active amides and amines with fluorine-containing heterocycles 1. Novel fluorine-containing heterocyclic derivatives of streptocide
Authors:Sokolov  V. B.  Aksinenko  A. Yu.  Epishina  T. A.  Goreva  T. V.  Martynov  I. V.
Affiliation:1.Institute of Physiologically Active Substances, Russian Academy of Sciences, 1 Severnyi proezd, Chernogolovka, 142432, Moscow Region, Russian Federation
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Abstract:Three-component reaction of Piracetam, methyl trifluoropyruvate and 1,3-binucleophiles, such as 6-aminouracils, 6-aminothiouracils, 4-(4-tolylamino)pent-3-en-2-one and N-substituted ureas, has been studied. This reaction resulted in fluorinated heterocyclic derivatives of Piracetam.
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