Synthesis and characterization of some chalcones and their cyclohexenone derivatives |
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Authors: | Thekke V Sreevidya Badiadka Narayana and Hemmige S Yathirajan |
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Institution: | (1) Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan;(2) School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK; |
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Abstract: | A series of chalcones and their derivatives have been synthesized. Chalcones, 1-(1,3-benzodioxol-5-yl)-3-(aryl)-prop-2-en-1-ones
were prepared by the aldol condensation of 1-(1,3-benzodioxol-5-yl)ethanones and aryl aldehydes. Based-catalyzed condensation
of 1-(1,3-benzodioxol-5-yl)-3-(aryl)prop-2-en-1-ones with ethyl acetoacetate yields corresponding ethyl 4-(1,3-benzodioxol-5-yl)-6-(aryl)-2-oxocyclohex-3-ene-1-carboxylates.
Some of the synthesized chalcones were reported in the literature; the newly synthesized compounds were characterized by single
crystal X-ray studies, IR, 1H-NMR and LCMS mass spectral analysis. |
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