Enhanced reactivity of electron-deficient enynes in the palladium-catalyzed homo-benzannulation of conjugated enynes |
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| Authors: | Saito Chounan Nogami Fukushi Tsuboya Yamada Kitahara Yamamoto |
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| Affiliation: | Institute for Chemical Reaction Science, Tohoku University, Sendai, Japan. |
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| Abstract: | We report the high reactivity of electron-deficient enynes in the homo-benzannulation of conjugated enynes in the presence of Pd(PPh3)4. The introduction of electron-withdrawing groups enabled us to carry out the benzannulation of 1-substituted enynes as well as 1,2- and 2,4-disubstituted enynes. Polysubstituted benzenes were prepared in a highly regioselective manner in good to excellent yields. |
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