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Crystallisation of zeolite mordenite and ZSM-5 without the aid of a template
Authors:P. N. Joshi  A. A. Shaikh  V. R. Chumbhale  B. S. Rao  V. P. Shiralkar
Affiliation:(1) Faculty of Pharmacy, Pharmaceutical Technology Department, Hacettepe University, 06100 Ankara, Türkiye;(2) Laboratorie de Pharmacie Galénique et de Biopharmacie, URA CNRS 1218, Université Paris Sud, 92296 Chatenay-Malabry, Cedex, France
Abstract:A complex of tenoxicam withbeta-cyclodextrin was prepared by using co-grinding and freeze drying methods. The resulting products were studied by the solubility method, ultraviolet and infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry. The dissolution behaviour of the products was also examined. The dissolution rate of the co-ground and freeze-dried products was faster than that of the pure drug and the physical mixture of drug andbeta-cyclodextrin. The enhanced dissolution rate of the products might be attributed to the amorphous state, the increased wettability of the drug and the inclusion complex formation.
Keywords:Tenoxicam/  /content/w66147m180463p86/xxlarge946.gif"   alt="  beta"   align="  MIDDLE"   BORDER="  0"  >-cyclodextrin complexation  freeze-drying method  co-grinding method  characterization of inclusion complexes
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