ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL LINES via DRUG PHOTO ACTIVATION |
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| Authors: | Alessandra Andreoni Alberto Colasanti Annamaria Kisslinger Mlchele Mastrocinque Giuseppe Portella Patrizia Riccio Giuseppe Roberti |
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| Affiliation: | C.N.R., Centra Endocrinologia ed Oncologia Sperimentale (C.E.O.S.), 80131 Napoli;Dipartimento di Fisica, University of Milano, 22100 Como;Dipartimento di Biologia e Patologia Cellulare e Molecolare, University of Naples, 80131 Napoli;Fondazione "Sen. G. Pascale," Istituto Nazionale per lo Studio e la Cura dei Tumori, 80131 Napoli;Dipartimento di Scienze Fisiche, University of Naples, 80125 Napoli, Italy |
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| Abstract: | Abstract— We have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (Fisher rat thyroid cells, FRTL-5) and to two neoplastic cell lines, a thyroid carcinoma (TK-6) and its lung metastasis (MPTK-6). Whereas the cell lines are equally sensitive to the drug in the dark, if irradiated during incubation with daunomycin (86 J/cm2 at 488 nm), they become more and differently sensitive. Namely, the drug doses producing 50% mortality decrease by factors of about 22, 28 and 16 for FRTL-5, TK-6 and MPTK-6 cell lines, respectively. This result correlates with differences in drug uptake and resistance observed in the normal and neoplastic cell lines. |
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