Potentiometric Studies on SomeCephalosporin Complexes |
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Authors: | Ahmed A Abdel Gaber Othman A Farghaly Mahmoud A Ghandour Hamdy S El-Said |
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Institution: | (1) Chemistry Department, Faculty of Science, Minia University, Minia, Egypt, EG;(2) Chemistry Department, Faculty of Science, South Valley University, Qena, Egypt, EG;(3) Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt, EG |
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Abstract: | Summary. The interaction of Ca(II), Cu(II), Zn(II), Pb(II), and La(III) ions with the antibiotics cephalexin, cefadroxil, cephaloridine,
and cefoperazone as secondary ligands was investigated potentiometrically. The formation constants were determined for a ligand-to-metal
ratio of 1:1 at 25°C and KNO3. The protonation constants of the complexes were evaluated for the system . The order of stability of the binary and ternary complexes were examined. It was found that glycine adds preferably M(II)-cephalosporin] rather than to the aqueous complexes of M(II). In all cases 1:1:1 complexes were formed.
Received February 4, 2000. Accepted (revised) May 10, 2000 |
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Keywords: | , ,Potentiometry, Glycine, Cephalosporins, Complexes, |
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