The Crystal and Molecular Structure of a Polymorph and a Pseudo-Polymorph of Droperidol |
| |
Authors: | Andris Actins Reinis Arajs Sergejs Belakovs Liana Orola Mikelis Valdis Veidis |
| |
Institution: | (1) Faculty of Chemistry, University of Latvia, Kr. Valdemara 48, Riga, 1013, Latvia;(2) Latvia Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia |
| |
Abstract: | Abstract Crystals of two crystal modifications of droperidol: a hemihydrate (1) and the z polymorph (2), have been isolated and their structure determined using X-ray diffraction methods. Droperidol hemihydrate crystallized
in the triclinic space group P − 1, with unit cell parameters a = 6.2842(15), b = 10.1473(8), c = 16.1850(2) ?; α = 102.554(9); β = 91.917(14); γ = 99.316(12)°; V = 991.6(3) ?3, and Z = 2. The droperidol z polymorph crystallized in the monoclinic space group P21/c, with unit cell parameters a = 20.0406(8), b = 7.4955(4), c = 12.9733(5) ?; β = 98.089(2)°; V = 1929.39(15) ?3, and Z = 4. In 1 and 2 two molecules of droperidol are joined by two N–H···O hydrogen bonds. The structure of 1 shows a possible additional hydrogen bond linking the two droperidol molecules via the water molecule.
Graphical Abstract
The crystal and molecular structure of a polymorph and a pseudo-polymorph of droperidol
A. Actins, R. Arajs, S. Belakovs, L. Orola, and M. V. Veidis
Crystals of two crystal modifications of droperidol: a hemihydrate and the z polymorph have been isolated and their structure determined using single crystal X-ray diffraction methods.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
| |
Keywords: | Droperidol Polymorph Pseudo-polymorph Crystal structure Hemihydrate Hydrogen bonding |
本文献已被 SpringerLink 等数据库收录! |
|