Ir(III)‐Catalyzed C7‐Position‐Selective Oxidative CH Alkenylation of Indolines with Alkenes in Air |
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| Authors: | Dr. Shiguang Pan Takayuki Wakaki Naoto Ryu Prof. Dr. Takanori Shibata |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, Waseda University, Shinjuku, Tokyo 169‐8555 (Japan), Fax: (+81)?3‐5286‐8098;2. Japan Science and Technology Agency (JST), 4‐1‐8 Honcho, Kawaguchi, Saitama 332‐0012 (Japan) |
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| Abstract: | An efficient method for C7‐position‐selective alkenylation of N‐substituted indolines with alkenes is reported. Various 7‐alkenylindolines were obtained in moderate to excellent yields in air in the presence of catalytic amounts of [Cp*IrCl2]2, AgOTf, and Cu(OAc)2. The protocol relies on the use of a carbonyl or carbamoyl group on the nitrogen atom of indoline as a directing group and is potentially applicable to the synthesis of 7‐alkenylindoles and 7‐alkylindoles. |
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| Keywords: | alkenes alkenylation C– H activation indoline iridium |
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