Ir(III)‐Catalyzed C7‐Position‐Selective Oxidative CH Alkenylation of Indolines with Alkenes in Air |
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| Authors: | Dr Shiguang Pan Takayuki Wakaki Naoto Ryu Prof?Dr Takanori Shibata |
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| Institution: | 1. Department of Chemistry and Biochemistry, Waseda University, Shinjuku, Tokyo 169‐8555 (Japan), Fax: (+81)?3‐5286‐8098;2. Japan Science and Technology Agency (JST), 4‐1‐8 Honcho, Kawaguchi, Saitama 332‐0012 (Japan) |
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| Abstract: | An efficient method for C7‐position‐selective alkenylation of N‐substituted indolines with alkenes is reported. Various 7‐alkenylindolines were obtained in moderate to excellent yields in air in the presence of catalytic amounts of Cp*IrCl2]2, AgOTf, and Cu(OAc)2. The protocol relies on the use of a carbonyl or carbamoyl group on the nitrogen atom of indoline as a directing group and is potentially applicable to the synthesis of 7‐alkenylindoles and 7‐alkylindoles. |
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| Keywords: | alkenes alkenylation C– H activation indoline iridium |
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