Multifunctional Core–Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo |
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| Authors: | Dr. Yin‐Yin Chen Dr. Ping‐An Ma Dr. Dong‐Mei Yang Yuan Wu Dr. Yun‐Lu Dai Dr. Chun‐Xia Li Prof. Jun Lin |
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| Affiliation: | 1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (P.R. China);2. University of the Chinese Academy of Sciences, Beijing 100049 (P.R. China) |
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| Abstract: | Multifunctional, mesoporous, silica‐coated upconversion luminescent/magnetic NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2? PEG (referred to as UCNPS; PEG=polyethylene glycol) nanocomposites were fabricated through a phase‐transfer‐assisted surfactant‐templating coating process, followed by hydrophilic polymer (PEG) functionalization to improve the stability and biocompatibility. The UCNP core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (MR) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. Proof‐of‐principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/MR dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers. |
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| Keywords: | imaging agents luminescence magnetic properties medicinal chemistry nanostructures |
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