Synthesis of phosphorylated sulfoximines and sulfinamides and their application as ligands in asymmetric metal catalysis |
| |
Authors: | Eduard B. BenetskiyCarsten Bolm |
| |
Affiliation: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany |
| |
Abstract: | Starting from inexpensive materials and following simple protocols various N-phosphorylated sulfoximines and sulfinamides have been synthesized. The newly prepared compounds were then applied as chiral ligands in asymmetric transition metal catalysis. Phosphorus triamide-type ligands derived from (S)-glutamic acid were found to be the most efficient stereoselectors in enantioselective palladium-catalyzed allylic substitutions (up to 97% ee). On the other hand, diamidophosphite-type structures stemming from (S)-proline were the best ligands in rhodium-catalyzed hydrogenation reactions (up to 84% ee). |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |