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Lipases A and B from Candida antarctica in the enantioselective acylation of ethyl 3-heteroaryl-3-hydroxypropanoates: aspects on the preparation and enantiopreference |
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| Authors: | Jürgen Brem Arto LiljebladCsaba Paizs Monica Ioana To?aFlorin-Dan Irimie Liisa T Kanerva |
| Institution: | a Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, FIN-20014, Finland b Department of Biochemistry and Biochemical Engineering, Babe?-Bolyai University of Cluj-Napoca, Ro-400028 Cluj-Napoca, Arany János 11, Romania |
| Abstract: | The preparative scale kinetic resolution of racemic ethyl 2- and 3-furyl- and 2- and 3-thienyl-3-hydroxypropanoates has been performed by Candida antarctica lipases A and B with vinyl esters. A study based on the present work together with the literature has been carried out in terms of lipase enantiopreference and substrate structure. We also discuss the excellent behavior of the lipase A in O-acylations of secondary alcohols with respect to enantiopreference. |
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