Cytotoxic isoquinoline quinones from sponges of the genus Petrosia |
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| Authors: | Sandoval Imelda T Davis Rohan A Bugni Tim S Concepcion Gisela P Harper Mary Kay Ireland Chris M |
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| Institution: | Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA. |
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| Abstract: | Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (1) and the known compounds renierone (2) and O-demethylrenierone (3). The structures of these isoquinoline quinones were determined by interpretation of spectroscopic data. Compounds 1, 2 and 3 were cytotoxic against the HCT 116 human colon carcinoma cell line with IC50 values of 45, 24 and 34 microg/mL, respectively. |
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