Solution crystallisation via a submerged liquid-liquid phase boundary: oiling out |
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Authors: | Bonnett P E Carpenter K J Dawson S Davey R J |
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Institution: | Process Studies Group, Syngenta, Huddersfield, West Yorkshire, UK HD2 1FF. |
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Abstract: | In many situations the process of crystallisation from solution is known to occur via metastable crystalline states (polymorphs or solvates). Here we present what we believe to be a novel example of small molecule crystallisation in which the initial separation of a solute rich liquid phase precedes the crystallisation event. We believe this occurs because a submerged liquid-liquid phase boundary is accessible within the metastable zone of the crystal nucleation process. |
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