l-Proline as an efficicent catalyst for the multi-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in water |
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Authors: | Hormi MecadonMd. Rumum Rohman Iadeishisha KharbangarBadaker M. Laloo Icydora KharkongorMantu Rajbangshi Bekington Myrboh |
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Affiliation: | Department of Chemistry, North-Eastern Hill University, Permanent Campus, Umshing, Mawlai, Shillong 793022, India |
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Abstract: | An efficient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using l-proline (10 mol %) in water under mild reaction condition in excellent yields is established. A comparative study of l-proline with γ-alumina, basic alumina, and KF-alumina was also carried out. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated. |
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Keywords: | Four-component reaction smallcaps" >l-Proline Water Environmentally benign |
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