A highly selective solid phase extraction sorbent for pre-concentration of sameridine made by molecular imprinting |
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Authors: | L. I. Andersson A. Paprica T. Arvidsson |
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Affiliation: | 1. Bioanalytical Chemistry, Pharmaceutical and Analytical R&D, Astra Pain Control, 151 85, S?dert?lje, Swerden
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Abstract: | Summary A novel approach to solid phase extraction, based on the use of a highly selective molecularly imprinted polymer, is presented. The versatility of this type of sorbent for solid phase extraction was demonstrated in a model batch-wise pre-concentration of sameridine prior to gas chromatography. Problems associated with leakage of remaining imprint molecules during the desorption phase could be eliminated by the use of a close structural analogue of sameridine as the imprint species. It was found that a major benefit of the imprinted polymer was its specificity, which lead to distinctly cleaner chromatographic traces and ability to improve sensitivity by extracting sameridine from larger sample volumes. |
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Keywords: | Gas chromatography Solid phase extraction Sample pre-concentration Pre-determined selectivity Synthetic polymer |
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