Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases |
| |
Authors: | Seibert Simon F Eguereva Ekaterina Krick Anja Kehraus Stefan Voloshina Elena Raabe Gerhard Fleischhauer Jörg Leistner Eckhard Wiese Michael Prinz Heino Alexandrov Kirill Janning Petra Waldmann Herbert König Gabriele M |
| |
Institution: | Institute for Pharmaceutical Biology, University of Bonn, D-53115 Bonn, Germany. |
| |
Abstract: | Chemical investigation of the marine fungus Ascochyta salicorniae led to the isolation of two new epimeric compounds, ascolactones A (1) and B (2), in addition to the structurally-related polyketides hyalopyrone (3), ascochitine (4), ascochital (5) and ascosalipyrone (6). The absolute configurations of the epimeric compounds 1 and 2 were assigned as (1R,9R) and (1S,9R), respectively, through simulation of the chiroptical properties using quantum-chemical CD calculations, and chiral GC-MS subsequent to oxidative cleavage (Baeyer-Villiger oxidation) of the side chain. In silico screening using the PASS software identified some of the A. salicorniae compounds (1-6) as potential inhibitors of protein phosphatases. Compound was found to inhibit the enzymatic activity of MPtpB with an IC(50) value of 11.5 microM. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|