A novel silver(i)-mediated DNA base pair |
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| Authors: | Zimmermann Nicole Meggers Eric Schultz Peter G |
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| Affiliation: | The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | We have generated a novel silver(I)-mediated unnatural DNA base pair consisting of two 2,6-bis(ethylthiomethyl)pyridine nucleobases SPy. This metallo-base pair has a remarkably high pairing stability and selectivity which rivals that of the natural base pairs dA:dT and dC:dG. UV-melting experiments revealed that the dSPy:dSPy self-pair can replace natural base pairs at multiple sites and still form stable DNA duplexes. |
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