| Study on the inclusion interaction of methylated-β-cyclodextrins with albendazole by spectrofluorimetry and its application |
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| 作者姓名： | Guo Yan Zhao Hao Wu Sheng Li Dong Li Ming Du |
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| 作者单位： | Analytical and Testing Center, Shanxi Normal University, Linfen 041004, China |
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| 基金项目： | AcknowledgmentThis research was supported by the Natural Science Foundation of Shanxi （No. 2007011027）. |
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| 摘 要： | The inclusion interaction between three types of methylated-β-cyclodextrins （Me-β-CDs） and albendazole （ABZ） was studied by spectrofluorimetry. The result showed that Me-β-CDs reacted with ABZ to form an inclusion complex, 1： 1 stoichiometry for Me- β-CDs-ABZ complex was established and its association constant have been determined from fluorescence data by Benesi- Hildebrand＇s method （double reciprocal plots）. It was noted that 2,6-DM-β-CD exhibited stronger binding ability than other Me-β- CDs. Based on the significant enhancement of fluorescence intensity of inclusion complex, a simple and highly sensitive fluorimetric method is proposed for the determination of ABZ in the presence of 2,6-DM-β-CD. The proposed method was successfully applied to the determination of ABZ in tablets and human urine.
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| 关 键 词： | 甲基化 阿苯达唑 分光荧光法 化学 |
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