Triplex-directed covalent cross-linking of a DNA nanostructure |
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Authors: | David A Rusling Iris S Nandhakumar Tom Brown Keith R Fox |
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Affiliation: | Centre for Biological Sciences, University of Southampton, Highfield, Southampton, UK. K.R.Fox@soton.ac.uk D.A.Rusling@soton.ac.uk. |
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Abstract: | The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes. |
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