| Studies on Electrochemical Behavior of Bleomycin and Its Interaction with DNA at a Co／GC Ion Implantation Modified Electrode |
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| 引用本文： | 胡劲波
,李启隆
,尚军.Studies on Electrochemical Behavior of Bleomycin and Its Interaction with DNA at a Co／GC Ion Implantation Modified Electrode[J].中国化学,2002,20(3):267-271. |
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| 作者姓名： | 胡劲波 李启隆 尚军 |
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| 作者单位： | HU，Jing-Bo LI，Qi-Long SHANG，JunDepartment of Chemistry，Beijing Normal University，Beijing 100875，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No.2 9875 0 0 3)andtheResearchFundfortheDoctoralPro gramofHigherEducationofChina (No .980 0 2 70 9) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＩｏｎｉｍｐｌａｎｔａｔｉｏｎｉｓａｋｉｎｄｏｆｎｅｗｍａｔｅｒｉａｌｓｕｒｆａｃｅｍｏｄｉｆｉｃａｔｉｏｎｔｅｃｈｎｉｑｕｅ .Ｒｅｃｅｎｔｌｙ ,Ｌｉｅｔａｌ .1ｈａｖｅｌｅｄｔｈｉｓｔｅｃｈｎｉｑｕｅｉｎｔｏａｎａｌｙｔｉｃａｌｃｈｅｍｉｓｔｒｙａｎｄｍａｄｅｍｏｄｉ ｆｉｅｄｅｌｅｃｔｒｏｄｅｗｉｔｈｐａｒｔｉｃｕｌａｒｆｕｎｃｔｉｏｎ .Ｉｔｈａｓｂｅｅｎａｐ ｐｌｉｅｄｔｏｓｔｕｄｙｔｈｅｅｌｅｃｔｒｏｃｈｅｍｉｃａｌｂｅｈａｖｉｏｒｓａｎｄｔｈｅｄｅ ｔｅｒｍｉｎａｔ…
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| 关 键 词： | 电化学行为 博来霉素 争光霉素 脱氧核糖核酸 钴离子注入修改电极 DNA 玻璃碳电极 |
Studies on Electrochemical Behavior of Bleomycin and Its Interaction with DNA at a Co/GC Ion Implantation Modified Electrode |
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| HU,Jing-Bo LI,Qi-Long SHANG,Jun.Studies on Electrochemical Behavior of Bleomycin and Its Interaction with DNA at a Co/GC Ion Implantation Modified Electrode[J].Chinese Journal of Chemistry,2002,20(3):267-271. |
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| Authors: | HU Jing-Bo LI Qi-Long SHANG Jun |
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| Institution: | HU,Jing-Bo LI,Qi-Long SHANG,JunDepartment of Chemistry,Beijing Normal University,Beijing 100875,China |
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| Abstract: | Electrochemical investigation of Bleomycin (BLM) and its interaction with DNA at a Co/GC ion implantation modified electrode was reported for the first time. The electrochemical behavior of BLM at Co/GC modified electrode has been studied by linear sweep and cyclic voltammetry, The reaction of BLM with DNA formed an electrochemically nonactive complex, which resulted in a decrease in the BLM equilibrium concentration and its reduction current. The decrease in peak current was proportional to DNA concentration and could be used to determination DNA concentration. The equilibrium constant of DNA‐BLM complex β was determined to be 5.16 × 1016. The experiments of AES and XPS showed that Co was surely implanted into the surface of GCE (glassy carbon electrode) and the depth distribution of Co was in good agreement with Gaussian normal distribution; the implanted Co at GCE improved the electrocatalytic activity. |
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| Keywords: | Co/GC ion implantation modified electrode linear sweep voltammetry bleomycin DNA |
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