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Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens
Authors:Fernandes Daniara Cristina  Regasini Luis Octávio  Vellosa José Carlos Rebuglio  Pauletti Patrícia Mendonça  Castro-Gamboa Ian  Bolzani Vanderlan Silva  Oliveira Olga Maria Mascarenhas  Silva Dulce Helena Siqueira
Affiliation:NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-S?o Paulo State University, Brazil.
Abstract:Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox.
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