| 微波辐射下芳醛与活性亚甲基化合物的反应 |
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| 引用本文： | 屠树江,邓旭,周建峰,孙柏旺,冯骏材.微波辐射下芳醛与活性亚甲基化合物的反应[J].高等学校化学学报,2002,23(2):222-225. |
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| 作者姓名： | 屠树江 邓旭 周建峰 孙柏旺 冯骏材 |
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| 作者单位： | 南京大学化学化工学院,南京,210093 |
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| 摘 要： | 芳醛、5，5－二甲基－1，3－环己二酮、丙二酸亚异丙酯经微波辐射发生缩合、加成、环化及消去反应，一步合成了7，7－二甲基－4－芳基－2，5－二氧代－1，2，3，4，5，6，7，8－八氢喹啉和7，7－二甲基－4－芳基－5－氧代－3，4，5，6，7，8－六氢香豆素，反应在3－5min内完成，产率优良。产物的结构经红外及核磁共振等方法确证。
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| 关 键 词： | 芳醛 活性亚甲基化合物 X射线衍射 微波辐射 缩合反应 加成反应 环化反应 消去反应 |
| 文章编号： | 0251-0790(2002)02-0222-04 |
Studies on the Reaction of Aromatic Aldehyde with Active Methylene Compound under Microwave Irradiation |
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| Abstract: | A series of 4 aryl 7,7 dimethyl 2, 5 dioxo 1,2,3,4,5,6,7,8 octahydroquinoline (4) and 4 aryl 7,7 dimethyl 5 oxo 3,4,5,6,7,8 hexahydrocoumarin (5) were synthesized from aromatic aldehydes (1), 5,5 dimethyl 1,3 cyclohexandione (2) and isopropylidene malonate (3) by the condensation, addition, cyclization and elimination reactions under microwave irradiation under different conditions. The reactions were completed in 3-5 min with good yields. The structure of the products were established on IR, 1H NMR, elemental analysis and X ray diffraction. |
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| Keywords: | Aromatic aldehyde Active methylene compound Microwave Crystal X ray diffraction |
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