Functional sulfur amino acid production and seawater remediation system by sterile Ulva sp. (chlorophyta) |
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Authors: | Shin Hirayama Masashi Miyasaka Hideomi Amano Yoshito Kumagai Nobuhiro Shimojo Teruyoshi Yanagita Yoshiro Okami |
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Affiliation: | (1) Advanced Technology Research Center, Mitsubishi Heavy Industries, Ltd., 1-8-1, Sachiura, Kanazawa-Ku, 236-8515 Yokohama, Japan;(2) Yokohama Dockyard & Machinery Works, Mitsubishi Heavy Industries, Ltd., 12, Nishiki-Cho, Naka-Ku, 231-8715 Yokohama, Japan;(3) Faculty of Bioresources, Mie University, Tsu, 514-8507 Mie, Japan;(4) Institute of Community Medicine, University of Tsukuba, Tsukuba, 305-8575 Ibaraki, Japan;(5) Department of Applied Biological Sciences, Saga University, 840-8502 Saga, Japan;(6) Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021 Tokyo, Japan |
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Abstract: | Sterile Ulva, which is a macroalga, has the potential to grow stably; therefore, this seaweed is expected to be an efficient resource of functional food containing various nutrients such as sulfur amino acids, proteins, carbohydrates, and minerals. Ulva latuca was selected from the "Marine Park" in Tokyo Bay, and its growth rate (g-dry/[m2.d]) was measured using model reactors located on the land or on the surface of the sea at Yokohama. The growth rate of U. lactuca was recorded to be approx 20 g-dry/(m2.d), which is estimated to be 10 times greater than that in a natural field in the Marine Park. In addition, this growth rate was higher than that of conventional crops such as corn and rice on a farm or paddy. These data led us to newly design and propose a floating type of labor-efficient U. lactuca production system. d-Cysteinolic acid, which is included in U. lactuca as a major sulfur amino acid, inhibited the Fenton reaction, resulting in suppression of hydroxyl radical production and singlet oxygen. Addition of the sulfur amino acid (1 microM) to HepG2 cells markedly decreased the intracellular triglyceride level. Hence, this proposed facility also has the potential for industrial production of a valuable resource for the primary prevention of lifestyle-related diseases using enriched or eutrophied seawater. |
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Keywords: | font-variant:small-caps" >d-Cysteinolic acid reactive oxygen triglyceride Ulva lactuca seawater |
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