Synthesis of heterocyclic compounds possessing the 4H-thieno[3,2-b]pyrrole moiety |
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Authors: | Ilyin Alexey P Dmitrieva Irina G Kustova Veronika A Manaev Alexandre V Ivachtchenko Alexandre V |
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Institution: | Chemical Diversity Research Institute, Khimki, Moscow reg. 114401, Russia. |
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Abstract: | A series of novel heterocyclic combinatorial libraries containing 4H-thieno3,2-b]pyrrole, thieno2',3':4,5]-pyrrol1,2-d]1,2,4]triazine and thieno2',3':4,5]pyrrolo1,2-a]pyrazine heterocyclic moieties were obtained by parallel solution-phase synthesis. Key steps include different reactions of initial alkyl 4H-thieno3,2-b]-pyrrole-5-carboxylates, such as alkylation with alkylating agents; transformation of the carboxylate group into different reactive functionalities, followed by reactions with electrophilic species; intramolecular cyclizations; and amide bond formation. Simple manual techniques for parallel reactions were coupled with easy purification procedures to give high-purity final products. |
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