| Tb(III) Speciation in Human Blood Plasma by Computer Simulation |
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| 引用本文： | Xing LU,Yue WANG,Hai Yuan ZHANG,Chun Ji NIU*,Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022. Tb(III) Speciation in Human Blood Plasma by Computer Simulation[J]. 中国化学快报, 2001, 0(9) |
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| 作者姓名： | Xing LU Yue WANG Hai Yuan ZHANG Chun Ji NIU* Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 |
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| 作者单位： | Xing LU，Yue WANG，Hai Yuan ZHANG，Chun Ji NIU*，Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics，Changchun Institute of Applied Chemistry，Chinese Academy of Sciences，Changchun 130022 |
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| 摘 要： | With the wide application of rare earth fertilizer and medicines1, more and more rare earths enter into environment, and also into human body via food chain. Now it is very urgent to study the biological effect of rare earths on human health and environment. After entering into human body by whatever route, lanthanide ions are transported to secondary deposition sites mainly via the plasma in the blood stream. So it is very important to study lanthanides speciation in human blood plasma. Becau…
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Tb(III) Speciation in Human Blood Plasma by Computer Simulation |
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| Xing LU,Yue WANG,Hai Yuan ZHANG,Chun Ji NIU,Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun. Tb(III) Speciation in Human Blood Plasma by Computer Simulation[J]. Chinese Chemical Letters, 2001, 0(9) |
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| Authors: | Xing LU Yue WANG Hai Yuan ZHANG Chun Ji NIU Jia Zuan NI Key Laboratory of Rare Earth Chemistry Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun |
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| Affiliation: | Xing LU,Yue WANG,Hai Yuan ZHANG,Chun Ji NIU*,Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022 |
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| Abstract: | A multi-phase model was developed and Tb(III) speciation in human blood plasma was studied. At a concentration below 3.744(10-4mol/L (or at the concentration), Tb(III) is mostly bound to phosphate to form precipitate of TbPO4. As the concentration of Tb(III) increases, phosphate is exceeded and another kind of precipitate of Tb2(CO3)3 appears. Among soluble Tb(III) species, Tb(III) mainly distribute in [Tb (Tf)] at low concentration and in [Tb (HSA)], [Tb2 (Tf)], [Tb (IgG)], [Tb (Lactate)]2+, [Tb (CitArgH)] and free Tb(III) at high concentration. |
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| Keywords: | Terbium (III) speciation human blood plasma computer simulation. |
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