| Determination of the Absolute Configuration of Rohitukine |
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| 作者姓名： | DongHuiYANG ShaoQingCAI YuYingZHAO |
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| 作者单位： | DepartmentofNaturalMedicines,SchoolofPharmaceuticalSciences,PekingUniversity,Beijing100083 |
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| 摘 要： | The absolute configuration of rohitukine, isolated from the stem-bark of Dysoxylum binectariferum, was determined to be 5,7-dihydroxy-2-methyl-8-4-(3S, 4R-3-hydroxy-1-methyl)-piperidinyl]-4H-l-benzopyran-4-one by X-ray crystallographic analysis on the crystal of,4-bromobenzoyl derivatives of rohitukine. At the same time, the modified Mosher method was proved to be unsuitable for determining the absolute configuration of C-3‘ position in rohitukine.
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| 关 键 词： | 结构分析 红果樫木茎皮提取物 Rohitukine 抗炎活性 中药 |
Determination of the Absolute Configuration of Rohitukine |
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| DongHuiYANG ShaoQingCAI YuYingZHAO.Determination of the Absolute Configuration of Rohitukine[J].Chinese Chemical Letters,2003,14(7):720-723. |
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| Authors: | Dong Hui YANG Shao Qing CAI Yu Ying ZHAO HONG Liang |
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| Abstract: | The absolute configuration of rohitukine, isolated from the stem-bark of Dysoxylum binectariferum, was determined to be 5,7-dihydroxy-2-methyl-8-4-(3S, 4R-3-hydroxy-1-methyl) -piperidinyl]-4H-1-benzopyran-4-one by X-ray crystallographic analysis on the crystal of 4-bromobenzoyl derivatives of rohitukine. At the same time, the modified Mosher method was proved to be unsuitable for determining the absolute configuration of C-3 position in rohitukine. |
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| Keywords: | Dysoxylum binectariferum absolute configuration rohitukine |
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