| 一锅法合成3-腈基-4苯并吡喃酮类化合物 |
| |
| 引用本文： | 陈志卫,杨艳艳,闫伟华,苏为科.一锅法合成3-腈基-4苯并吡喃酮类化合物[J].合成化学,2010,18(1). |
| |
| 作者姓名： | 陈志卫 杨艳艳 闫伟华 苏为科 |
| |
| 作者单位： | 浙江工业大学,药学院,浙江省制药工程重点实验室,浙江,杭州,310014 |
| |
| 摘 要： | 以各种取代的邻羟基苯乙酮为起始原料,经Vilsmeier试剂环合得中间体3-甲酰基色酮,不经分离纯化,直接与盐酸羟胺反应合成了一系列3-腈基-4苯并吡喃酮类化合物,总收率47%~74%,其结构经1HNMR,IR和MS确证。
|
| 关 键 词： | 苯并吡喃酮 邻羟基苯乙酮 Vilsmeier试剂 一锅法 合成 |
One-pot Synthesis of 3-Cyano-4-benzopyrones |
| |
| CHEN Zhi-wei,YANG Yan-yan,YAN Wei-hua,SU Wei-ke.One-pot Synthesis of 3-Cyano-4-benzopyrones[J].Chinese Journal of Synthetic Chemistry,2010,18(1). |
| |
| Authors: | CHEN Zhi-wei YANG Yan-yan YAN Wei-hua SU Wei-ke |
| |
| Abstract: | 3-Cyano-4-benzopyrones in overall yields of 47%~74% were synthesized from various substituted o-hydroxyacetophenones by one-pot method of cyclization in the presence of Vilsmeier reagent,and followed by treatment with hydroxylamine hydrochloride.The structures were confirmed by ~1H NMR,IR and MS. |
| |
| Keywords: | benzopyrones o-hydroxyacetophenones Vilsmeier reagent one-pot synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
