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Asymmetric synthesis of (+)-chloriolide |
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| Authors: | Tapas Das |
| Institution: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India |
| Abstract: | An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule. |
| Keywords: | Medium ring macrolides Enzymatic kinetic resolution (EKR) Asymmetric alkynylation Macrolactonization Asymmetric total synthesis |
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