A convenient and efficient synthesis of C-carbamoyl-1,2,3-triazoles from alkyl bromide by a one-pot sequential addition: conversion of ester to amide using Zr(Ot-Bu)4 |
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| Authors: | Dongsik Yang |
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| Affiliation: | Department of Chemistry, Kwangwoon University, Seoul 139-701, Republic of Korea |
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| Abstract: | A convenient and efficient one-pot sequence has been developed for the synthesis of C-carbamoyl-1,2,3-triazoles from alkyl bromide using (i) sodium azide, (ii) methyl propiolate and copper iodide, and (iii) amines, zirconium tert-butoxide, and 1-hydroxybenzotriazole, under microwave irradiation. The sequential reactions in one-pot provided the desired C-carbamoyl-1,2,3-triazoles in excellent yields. |
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| Keywords: | One-pot sequence C-Carbamoyl-1,2,3-triazole Zirconium tert-butoxide Microwave irradiation |
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