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A mild titanium-based system for the reduction of amides to aldehydes |
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| Authors: | Stéphane Laval Alain Favre-Reguillon Patrice Demonchaux Marc Lemaire |
| Institution: | a Laboratoire CASYEN, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), CNRS, UMR5246, Université Lyon 1, Campus de la Doua, Bât. Curien-CPE, 3e étage, 43, Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France b Laboratoire de Chimie Organique, UMR7084, Conservatoire National des Arts et Metiers, 2 Rue Conté, 75003 Paris, France c Minakem, 145, Chemin des Lilas, 59310 Beuvry la Foret, France d Rhodia, Lyon Research Center, 85, Avenue des Frères Perret, BP 62, 69192 Saint-Fons Cedex, France |
| Abstract: | A mild method for the reduction of amides to aldehydes using 1,1,3,3-tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The reaction occurs under mild conditions and allows the reduction of aromatic as well as aliphatic, tertiary amides to the corresponding aldehydes, in good yields. This methodology was extended to the reduction of aromatic secondary and primary amides to the corresponding aldehydes. |
| Keywords: | Aldehydes Amides Reduction 1 1 3 3-Tetramethyldisiloxane Titanium |
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