Fe(II)-catalyzed N-alkylation of sulfonamides with benzylic alcohols |
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| Authors: | Xinjiang Cui Feng Shi Yan Zhang |
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| Institution: | a Centre for Green Chemistry and Catalysis, Lanzhou Institute of Chemical Physics, CAS, Lanzhou 730000, China
b Graduate School of Chinese Academy and Science, Beijing 100049, China |
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| Abstract: | The FeCl2/K2CO3 catalyst system was developed successfully for the N-alkylation of sulfonamides with benzylic alcohols via borrowing hydrogen method. XPS analysis suggested a possible catalyst cycle between Fe(II) and Fe(0). Under the optimized condition, the scope of the protocol was demonstrated in 21 different alkylation reactions. High yields, in general >90%, are achieved in most cases. |
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| Keywords: | Sulfonamide Alkylation Alcohol Iron |
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