Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole |
| |
Authors: | Amanda E Sparke |
| |
Institution: | Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom |
| |
Abstract: | The synthesis of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, which undergoes a nucleophilic substitution with pyridine in the absence of additional base, is reported. The key steps are the reaction of 1,2-phenylenediamine to give exclusively the mono-substituted product and the avoidance of minor by-products via the use of glycolic acid for the cyclisation step. The X-ray structures of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazolium chloride and 1-1-(4-nitrobenzyl)benzimidazol-2-ylmethyl]pyridinium chloride are presented. |
| |
Keywords: | Benzimidazole Antagonist Anti-viral Chelators synthesis |
本文献已被 ScienceDirect 等数据库收录! |
|