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Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine |
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| Authors: | Tingting Mo Xueling Mi Erin E Milner Peter Wipf |
| Institution: | a Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA b Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, PA 15260, USA c Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Av., Silver Spring, MD 20910, USA |
| Abstract: | The 8-SF5 analog of mefloquine was synthesized in nine steps from commercially available starting materials and in five steps from a novel ortho-SF5-substituted aniline intermediate. |
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