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Synthesis of imidazo[1,2a]pyridines via three-component reaction of 2-aminopyridines, aldehydes and alkynes
Authors:Ping Liu  Li-song Fang  Guo-qiang Lin
Institution:a School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
b Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
Abstract:A novel three-component reaction towards the synthesis of imidazo1,2a]pyridines was independently developed based on 2-aminopyridines, aldehydes and alkynes, and thereby imidazo1,2a]pyridines were obtained in acceptable yields by the CuSO4/TsOH catalyzed three-component reaction.
Keywords:Multicomponent reaction  Imidazol[1  2a]pyridines  Catalysis  Heterocycles
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