Synthesis of imidazo[1,2a]pyridines via three-component reaction of 2-aminopyridines, aldehydes and alkynes |
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Authors: | Ping Liu Li-song Fang Guo-qiang Lin |
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Institution: | a School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China b Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China |
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Abstract: | A novel three-component reaction towards the synthesis of imidazo1,2a]pyridines was independently developed based on 2-aminopyridines, aldehydes and alkynes, and thereby imidazo1,2a]pyridines were obtained in acceptable yields by the CuSO4/TsOH catalyzed three-component reaction. |
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Keywords: | Multicomponent reaction Imidazol[1 2a]pyridines Catalysis Heterocycles |
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