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Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation |
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| Authors: | Shwu-Jen Wu Tsong-Long Hwang Susan Morris-Natschke Tian-Shung Wu |
| Affiliation: | a Department of Medical Technology, Chung Hua University of Medical Technology, Tainan 717, Taiwan b Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan c Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan d Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA e Department of Pharmacy, China Medical University, Taichung 401, Taiwan |
| Abstract: | Salviatalin A (1) and salvitrijudin A (2), two diterpenes with novel skeletons, were isolated from the roots of Salvia digitaloides. Their structures were determined using 1D, 2D NMR, and HRESI-MS spectroscopic analyses. Salviatalin A (1) from bioassay-guided fractionation showed a potent inhibitory effect on superoxide anion production in GMLP/CB-activated human neutrophils as well as other anti-inflammatory effects. A plausible biosynthetic pathway is also discussed. |
| Keywords: | Salviatalin A Salvitrijudin A Salvia digitaloides Anti-inflammatory effects |
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